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We studied the endocrine and subjective responses that followed acute administration of the 5-HT1A receptor agonist buspirone (0.5 mg/kg orally) in 11 male patients with chronic fatigue syndrome (CFS) and a group of matched healthy controls. Patients with CFS had significantly higher plasma prolactin concentrations and experienced more nausea in response to buspirone than did controls. However, the growth hormone response to buspirone did not distinguish CFS patients from controls. Our data question whether the enhancement of buspirone-induced prolactin release in CFS is a consequence of increased sensitivity of post-synaptic 5-HT1A receptors. It is possible that the increased prolactin response to buspirone in CFS could reflect changes in dopamine function.

Original publication

DOI

10.1016/0165-0327(96)00075-4

Type

Journal article

Journal

J Affect Disord

Publication Date

04/11/1996

Volume

41

Pages

71 - 76

Keywords

Adolescent, Adult, Buspirone, Fatigue Syndrome, Chronic, Humans, Male, Middle Aged, Prolactin, Serotonin Receptor Agonists