Model-guided analysis of beta band oscillations in the basal ganglia

"Oscillations in the basal ganglia have been in length investigated due to its relationship with Parkinson's disease. More specifically, beta band oscillations show a close relationship with bradykinesia in disease, and with the suppression of motor movements in healthy individuals. Here I present two analysis approaches which use computational models to interpret the available unit activity data. This combination of experimental and computational tools allow us to find a potential generator of beta oscillators, which nuclei are shaping these waves and what network connectivity is in closest agreement with the data."