D Gaffan
Professor
Brain mechanisms of memory and amnesia.
Research Areas
Medical Sciences Division Themes
- Neuroscience
Neuroscience Sub-Themes
Neuroscience Keywords
- Alzheimer's Disease
- Amnesia
- Brain Injury
- Cholinergic
- Cognitive Impairment
- Frontal Lobe
- Hippocampus
- Learning and Memory
- Memory
- Neocortex
- Neurophysiology
- Perirhinal Cortex
- Plasticity
- Prefrontal Cortex
- Temporal Lobes
Techniques and Equipment
Group Members
- DR ANNA MITCHELL
- DR PHILIP BROWNING
- DR MAKOTO KUSUNOKI
- DR NATASHA SIGALA
- DR ANDY LEE
- DR MIKIKO KADOHISA
Collaborators
- DR ELISABETH A MURRAY, NIH
- DR JOHN DUNCAN, MRC-CBSU CAMBRIDGE UK
- PROF KIM GRAHAM, CARDIFF UNIVERSITY
| Department | Department of Experimental Psychology |
|---|
We study effects of brain lesions on memory in macaque monkeys, using locally and chemically specific lesions. These experiments are linked to investigations of memory disorders in human patients and also to single-unit studies of brain activity in monkeys.
Sources of Funding
- MRC 2004- 2008
Selected Publications
- Barense M D, Gaffan D, and Graham K S (2007) The human medial temporal lobe processes online representations of complex objects. Neuropsychologia.
- Baxter Mark G and Gaffan David (2007) Asymmetry of attentional set in rhesus monkeys learning colour and shape discriminations. Q J Exp Psychol (Colchester), 60(1):1-8.
- Browning Philip GF, Easton Alexander, and Gaffan David (2007) Frontal-temporal disconnection abolishes object discrimination learning set in macaque monkeys. Cereb Cortex, 17(4):859-64.
- Wilson Charles RE, Gaffan David, Mitchell Anna S, and Baxter Mark G (2007) Neurotoxic lesions of ventrolateral prefrontal cortex impair object-in-place scene memory. Eur J Neurosci, 25(8):2514-22.
- Buckley Mark J and Gaffan David (2006) Perirhinal cortical contributions to object perception. Trends Cogn Sci, 10(3):100-7.
- Everling Stefan, Tinsley Chris J, Gaffan David, and Duncan John (2006) Selective representation of task-relevant objects and locations in the monkey prefrontal cortex. Eur J Neurosci, 23(8):2197-214.
- Lee Andy CH, Buckley Mark J, Gaffan David, Emery Tina, Hodges John R, and Graham Kim S (2006) Differentiating the roles of the hippocampus and perirhinal cortex in processes beyond long-term declarative memory: a double dissociation in dementia. J Neurosci, 26(19):5198-203.
- Murray Elisabeth A and Gaffan David (2006) Prospective memory in the formation of learning sets by rhesus monkeys (Macaca mulatta). J Exp Psychol Anim Behav Process, 32(1):87-90.
- Browning Philip GF, Easton Alexander, Buckley Mark J, and Gaffan David (2005) The role of prefrontal cortex in object-in-place learning in monkeys. Eur J Neurosci, 22(12):3281-91.
- Gaffan David (2005) Neuroscience. Widespread cortical networks underlie memory and attention. Science, 309(5744):2172-3.
