Anthony Monaco
Research Areas
Medical Sciences Division Themes
- Neuroscience
Neuroscience Sub-Themes
Neuroscience Keywords
| Web | Personal Website |
|---|---|
| Email (PA) | monacopa@well.ox.ac.uk |
| Department | Wellcome Trust Centre for Human Genetics |
Prof. Anthony Monaco
The Monaco Research Group works in two main areas:
(1) The genetics of neurodevelopmental disorders:
The Group is currently engaged in research on the genetics of the following single-gene (monogenic) neurological diseases: Chorea Acanthocytosis (CHAC) and Menkes disease.
(2) The positional cloning and functional characterization of monogenic neurological diseases:
The Group is also engaged in research on the genetics of the following neurodevelopmental disorders: autism, Specific Language Impairment (SLI) and developmental dyslexia. These are all complex genetic disorders.
Over the past 15 years or so, there has been remarkable success tracking down genes for single-gene disorders, such as cystic fibrosis, Duchenne muscular dystrophy and Huntington’s disease. But such approaches are not usually powerful enough for complex genetic disorders.
Recently, however, novel strategies have been developed that are more appropriate for finding genes influencing complex disorders.
Biography
Brief biography:
Anthony P Monaco received his undergraduate degree from Princeton University in 1981 and his MD-PhD from Harvard Medical School in the Medical Scientist Training Program.
At Harvard, he did his PhD studies in the Program in Neuroscience. His doctoral thesis involved the isolation of the gene responsible for X-linked Duchenne and Becker muscular dystrophy in the laboratory of Louis M Kunkel.
He was a post doctoral fellow in Hans Lehrach's laboratory at the Imperial Cancer Research Fund (ICRF) (now Cancer Research UK ) in London, working on the human genome project.
This was followed by four years as an ICRF senior scientist and head of the Human Genetics Laboratory at the Institute of Molecular Medicine, Oxford.
In 1995, he was awarded a Wellcome Trust Principal Research Fellowship and joined the Wellcome Trust Centre for Human Genetics (WTCHG) in Oxford, which has a focus on the genetics of common disease and includes multidisciplinary research in genetics, functional genomics, bioinformatics and structural biology.
The Monaco Research Group at the WTCHG focuses on the genetic basis of neurological and psychiatric disorders. This includes: autism, specific language impairment (SLI) and reading disorders (dyslexia).
In 1998 Anthony Monaco was appointed as Director of the WTCHG.
He held this post until October 2007, when he was appointed Pro-Vice-Chancellor, Planning and Resources at the University of Oxford.
Selected Publications
- Falcaro M, Pickles A, Newbury D F, Addis L, Banfield E, Fisher S E, Monaco A P, Simkin Z, and Conti-Ramsden G (2007) Genetic and phenotypic effects of phonological short-term memory and grammatical morphology in specific language impairment. Genes Brain Behav.
- Francks C, Maegawa S, Lauren J, Abrahams B S, Velayos-Baeza A, Medland S E, Colella S, Groszer M, McAuley E Z, Caffrey T M, Timmusk T, Pruunsild P, Koppel I, Lind P A, Matsumoto-Itaba N, Nicod J, Xiong L, Joober R, Enard W, Krinsky B, Nanba E, Richardson A J, Riley B P, Martin N G, Strittmatter S M, Moller H-J, Rujescu D, St Clair D, Muglia P, Roos J L, Fisher S E, Wade-Martins R, Rouleau G A, Stein J F, Karayiorgou M, Geschwind D H, Ragoussis J, Kendler K S, Airaksinen M S, Oshimura M, Delisi L E, and Monaco A P (2007) LRRTM1 protein is located in the endoplasmic reticulum (ER) in mammalian cells. Mol Psychiatry, 12(12):1057.
- Francks C, Maegawa S, Lauren J, Abrahams B S, Velayos-Baeza A, Medland S E, Colella S, Groszer M, McAuley E Z, Caffrey T M, Timmusk T, Pruunsild P, Koppel I, Lind P A, Matsumoto-Itaba N, Nicod J, Xiong L, Joober R, Enard W, Krinsky B, Nanba E, Richardson A J, Riley B P, Martin N G, Strittmatter S M, Moller H-J, Rujescu D, St Clair D, Muglia P, Roos J L, Fisher S E, Wade-Martins R, Rouleau G A, Stein J F, Karayiorgou M, Geschwind D H, Ragoussis J, Kendler K S, Airaksinen M S, Oshimura M, Delisi L E, and Monaco A P (2007) LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol Psychiatry, 12(12):1129-39.
- Holloway Z G, Grabski R, Szul T, Styers M, Coventry J, Monaco A P, and Sztul E (2007) Activation of ADP-ribosylation factor (Arf) regulates biogenesis of the ATP7A containing trans-Golgi network compartment and its Cu-induced trafficking. Am J Physiol Cell Physiol.
- Monaco Anthony P (2007) Is there a rational solution to the kidney shortage? Med Health R I, 90(3):89-90.
- Ruiz-Sandoval Jose L, Garcia-Navarro Victor, Chiquete Erwin, Dobson-Stone Carol, Monaco Anthony P, Alvarez-Palazuelos Lucia E, Padilla-Martinez Juan J, Barrera-Chairez Esperanza, Rodriguez-Figueroa Erika I, and Perez-Garcia Guillermo (2007) Choreoacanthocytosis in a mexican family. Arch Neurol, 64(11):1661-4.
- Velayos-Baeza Antonio, Toma Claudio, da Roza Stephanie, Paracchini Silvia, and Monaco Anthony P (2007) Alternative splicing in the dyslexia-associated gene KIAA0319. Mamm Genome, 18(9):627-34.
